Protein Details: Piezo-type mechanosensitive ion channel component 1
Protein ID
ICDB_Pro_0115
Protein Name
Piezo-type mechanosensitive ion channel component 1
Gene Name
Piezo1; Fam38a
Organism
Mus musculus (Mouse)
Length
2547 amino acids
AlphaFoldDB
AF-E2JF22-F1-model_v4.pdb
Function
Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER; most probably in its activated state; and subsequent stimulation of calpain signaling. In the kidney; may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as a shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology. Acts as a sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts; flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction; leading to assembly of cortical actomyosin fibers and myotube formation.
Sequence
Ligand Binding
Binding Site
Disease
Location
Expressed in bladder; colon; kidney and skin. Also expressed in bone marrow; liver; lung; spleen and erythrocytes (at protein level). Expressed in myoblasts (at protein level). Expressed in myoblasts (at protein level). Expressed in myoblasts (at protein level).
DOI ID
10.1126/science.1193270; 10.1016/j.immuni.2008.11.006; 10.1016/j.cell.2010.12.001; 10.1038/nature10812; 10.1182/blood-2013-02-482489; 10.1038/embor.2013.170; 10.1038/ncomms4520; 10.1073/pnas.1409233111; 10.1038/nature13701; 10.1038/s41467-018-04436-w; 10.1038/nature15247